Sean Payton made the gutsiest call in Super Bowl history, ambushing Peyton Manning and the Indianapolis Colts with a stunning ...

The 49ers will have to slow down Justin Jefferson, the 2022 offensive player of the year, and account for missing Christian ...

Niners cornerback Deommodore Lenoir is ready to face the QB he saw plenty in practice last season, adding he and Vikings' Sam ...

The Minnesota Vikings defense stops the San Francisco 49ers on a 4th-and goal thanks to a tipped pass from Vikings linebacker ...

Niners rookie WR Ricky Pearsall was a spectator at practice five days after being shot in the chest during an attempted ...

Minnesota Vikings Head Coach Kevin O'Connell joins Colin Cowherd to discuss how Sam Darnold's San Francisco 49ers tenure has ...

Playing without their best weapon in Christian McCaffrey, Jordan Mason and the 49ers sent a message to the rest of the league ...

No Christian McCaffrey. No problem. The San Francisco 49ers got into the win column right out of the gate in Week 1, ...

The San Francisco 49ers defeated Aaron Rodgers and the New York Jets 32-19 in their season opener at Levi's Stadium last ...

Prove it. Join our new, free-to-play Niners Wire Challenge. Answer eight questions below, plus a tie breaker correctly for ...