There’s no reason for the 49ers to deviate from Monday’s game plan. If the Vikings, with their dynamic, chaotic defense, can ...

The San Francisco 49ers have placed All-Pro running back Christian McCaffrey on injured reserve because of his lingering calf ...

Last season's AP Offensive Player of the Year missed the season opener, and now will have to sit out at least four more games ...

The lingering calf and Achilles tendon injuries means the All-Pro running back won't be eligible to return until a Thursday ...

Niners cornerback Deommodore Lenoir is ready to face the QB he saw plenty in practice last season, adding he and Vikings' Sam ...

The Niners ruled out the Pro Bowl running back Friday, with Niners head coach Kyle Shanahan telling reporters the team is ...

Minnesota Vikings Head Coach Kevin O'Connell joins Colin Cowherd to discuss how Sam Darnold's San Francisco 49ers tenure has ...

Christian McCaffrey was ruled out of the Minnesota game Friday and could be headed for injured reserve. McCaffrey was not on ...

Prove it. Join our new, free-to-play Niners Wire Challenge. Answer eight questions below, plus a tie breaker correctly for ...

The San Francisco 49ers announced Monday that star running back Christian McCaffrey will miss Monday night’s opener against ...

No Christian McCaffrey. No problem. The San Francisco 49ers got into the win column right out of the gate in Week 1, ...

Woody Johnson, the New York Jets owner, was recently interviewed by Fox News host Jesse Watters and took a subtle jab at the ...