Now comes the hard part for Kyle Shanahan — devising a game plan without Deebo Samuel and Christian McCaffrey.

SANTA CLARA, Calif. — The San Francisco 49ers have played games without Deebo Samuel Sr. in the last year and a half. And ...

Kyle Shanahan often couches any comments about the health of his players by noting the obvious: He’s not a doctor. However, ...

Alvin Kamara surpassed Christian McCaffrey in career touchdowns scored, ranking sixth-best among active players. Klint Kubiak ...

There are plenty of questions swirling around with the San Francisco 49ers right now with Christian McCaffrey on the Injured ...

San Francisco had its toughest practice of the week Thursday and McCaffrey was dealing with pain afterward, Shanahan said.

San Francisco 49ers running back Christian McCaffrey has been placed on injured reserve due to Achilles tendinitis, which ...

Here are all of the latest updates on which injured players are in and which are out for Week 2 of the NFL season: ...

The San Francisco 49ers are without running back Christian McCaffrey for at least four weeks. A report from NFL Media’s Ian ...

The San Francisco 49ers have ruled out Christian McCaffrey for Week 2 vs. the Minnesota Vikings — and potentially longer.

The San Francisco 49ers have placed All-Pro running back Christian McCaffrey on injured reserve because of his lingering calf ...

The reigning NFC champions faced a puzzling loss on Sunday. The San Francisco 49ers lost to the Minnesota Vikings 23-17 as ...