Ahead of a game against the Minnesota Vikings (1-0), the San Francisco 49ers (1-0) will be eyeing six players on their injury report. Meanwhile, the Vikings (1-0) will be tracking eight players on

Sunday will be McCaffrey's second missed game in San Francisco, only missing the 49ers' Week 18 regular-season finale against the Rams last season. The 49ers average 6.8 yards per play with McCaffrey on the field versus 5.3 yards per play when he is not on the field since he joined the team.

The 49ers placed Christian McCaffrey on injured reserve because of his lingering calf and Achilles tendon injuries.

Sam Darnold had an electric start in his Minnesota debut. The veteran threw for 208 yards, two touchdowns, and one interception in a win against the New York Giants. Heading into Week 2, the 49ers

The Minnesota Vikings got the better of their matchup against the San Francisco 49ers in 2023. That didn't stop 49ers cornerback Deommodore Lenoir from talking a little smack to his former teammate and Vikings starting quarterback Sam Darnold.

There isn't any love lost with the San Francisco 49ers and Minnesota Vikings quarterback Sam Darnold. The Vikings starting quarterback spent the 2023 season with the 49ers and backed up Brock Purdy. He started one game for the franchise during their Super Bowl runner-up season.