The Arizona Cardinals came out of the bye week and suffered their first loss in over a month, falling 16-6 to the Seattle Seahawks on the road. They saw their four-game winning streak snapped, they fell out of first place in the NFC West and out of the NFC playoff picture,

The only teams to rank ahead of the Seahawks were the Miami Dolphins, Tampa Bay Buccaneers, Denver Broncos, Los Angeles Chargers, Pittsburgh Steelers, Baltimore Ravens, Green Bay Packers, Minnesota Vikings, Kansas City Chiefs, Buffalo Bills, Philadelphia Eagles and Detroit Lions.

The Arizona Cardinals were rested, relatively healthy and had been playing some of their best football in years.