Third Ward is an area of Houston, Texas, United States, that evolved from one of the six historic wards of the same name. It is located in the southeast Houston management district. Third Ward, located inside the 610 Loop is immediately southeast of Downtown Houston and to the east of the Texas Medical Center. The ward became the center of Housto…Third Ward is an area of Houston, Texas, United States, that evolved from one of the six historic wards of the same name. It is located in the southeast Houston management district. Third Ward, located inside the 610 Loop is immediately southeast of Downtown Houston and to the east of the Texas Medical Center. The ward became the center of Houston's African-American community. Third Ward is nicknamed "The Tre".